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Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 57-62 doi: 10.1007/s11684-015-0389-8

Abstract:

The existence of cancer stem cells, stem-like cancer cells (SLCCs), or tumor-initiating cells is consideredis controversial because of two competing hypotheses: SLCCs are either transformed from tissue adult stemcells or dedifferentiated from transformed progenitor cells.Our previous research demonstrates that SLCCs are inducible by increasing genomic instability in cancercells.

Keywords： rabbit VX2 liver tumor     mitomycin C     AET     stem-like cancer cells     genomic instability    

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 462-476 doi: 10.1007/s11684-013-0270-6

Abstract: stem cell (CSC) populations.In this study, we demonstrate that a subset of cancer cells with CSC properties may be enriched intotumor spheroids under stem cell conditions from a non-small cell lung cancer cell line.Treating these CSC-like cells with gemcitabine alone and a combination of gemcitabine and the novel CHK1However, the CSC-like cells exhibited resistance to gemcitabine-induced apoptosis.

Keywords： drug resistance     cancer stem cell     checkpoint kinase 1 (CHK1)     PF-00477736     lung cancer     tumorigenicity    

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Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Frontiers of Medicine 2012, Volume 6, Issue 2,   Pages 112-121 doi: 10.1007/s11684-012-0199-1

Abstract:

Cancer stem cells (CSCs) have received considerable attention from the research community since theybecoming increasingly important for eradicating CSCs in heterogeneous tumor masses and to cure the cancer

Keywords： cancer stem cell     tumor model     drug discovery    

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Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous propertiespotential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-likecells in certain conditions.free culture media (ASFCM) in order to determine their potential for differentiation into sweat gland-likecells.

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

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Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 227-239 doi: 10.1007/s11684-021-0896-8

Abstract: Chronic stress impairs radial neural stem cell (rNSC) differentiation and adult hippocampal neurogenesisThe administration of CBD rescued depressive-like symptoms in CRS mice and prevented rNSCs overactivation

Keywords： cannabidiol     depression     radial neural stem cells     neurogenesis    

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Orlistat induces ferroptosis-like cell death of lung cancer cells

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 922-932 doi: 10.1007/s11684-020-0804-7

Abstract: synthesis is involved in the progression and treatment resistance of many types of cancers, including lung cancer; however, targeting the lipogenetic pathways for cancer therapy remains an unmet clinical need.cells in vitro and in vivo, and we found that orlistat, as a single agent, inhibited theproliferation and viabilities of lung cancer cells and induced ferroptosis-like cell death in vitroand other types of cancer.

Keywords： orlistat     ferroptosis     FAF2     lung cancer    

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Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 178-207 doi: 10.1007/s11684-020-0793-6

Abstract: Breast cancer is one of the most common malignancies that seriously threaten women’s health.In the process of the malignant transformation of breast cancer, metabolic reprogramming and immune evasionrepresent the two main fascinating characteristics of cancer and facilitate cancer cell proliferationBreast cancer cells generate energy through increased glucose metabolism.cells to evade the host’s immune system.

Keywords： breast cancer     metabolism     immunity     cancer stem cells    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalIn this study, telomerase activity was measured and compared in breast cancer stem cells and non-stemThe results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cellsactivity in stem cells was markedly increased.
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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stemcells in the bovine.

Keywords： bovine     embryonic     induced     pluripotent stem cells    

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Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 41-47 doi: 10.1007/s11684-012-0175-9

Abstract:

Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial sourceof early stem cells that can be readily manipulated.the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stemBy contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible.

Keywords： umbilical cord     mesenchymal stem cells     cutaneous regeneration    

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Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 372-378 doi: 10.1007/s11684-011-0164-4

Abstract: an emerging interdisciplinary field of research that uses several technological approaches including stemcells to repair tissues.Mesenchymal stem cells (MSCs), a type of adult stem cell, have generated a great amount of interest overmechanisms through which MSCs exert their therapeutic potential rely on some key properties of the cellsinto osteoblasts, chondrocytes, adipocytes, cardiomyocytes, hepatocytes, endothelial, and neuronal cells

Keywords： mesenchymal stem cells     differentiation     immunomodulation     regenerative medicine    

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Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 1-2 doi: 10.15302/J-FASE-2019251

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GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Frontiers of Medicine doi: 10.1007/s11684-023-1007-9

Abstract: Brain development requires a delicate balance between self-renewal and differentiation in neural stemcells (NSC), which rely on the precise regulation of gene expression.

Keywords： TET2     GID complex     neural stem cells     differentiation of neurons    

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Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 20-29 doi: 10.1007/s11684-014-0371-x

Abstract: As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs

Keywords： cellular therapy     transplantation     human umbilical cord     mesenchymal stem cells     ischemic stroke    

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Title Author Date Type Operation

Tumor growth and metastasis can be inhibited by maintaining genomic stability in cancer cells

Yi Liang,Qisheng Feng,Jian Hong,Futuo Feng,Yi Sang,Wenrong Hu,Miao Xu,Roujun Peng,Tiebang Kang,Jinxin Bei,Yixin Zeng

Journal Article

Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-likecells enriched with tumor spheroids from a non-small cell lung cancer cell line

Douglas D. Fang, Joan Cao, Jitesh P. Jani, Konstantinos Tsaparikos, Alessandra Blasina, Jill Kornmann, Maruja E. Lira, Jianying Wang, Zuzana Jirout, Justin Bingham, Zhou Zhu, Yin Gu, Gerrit Los, Zdenek Hostomsky, Todd VanArsdale

Journal Article

Identification of cancer stem cells provides novel tumor models for drug discovery

Douglas D. Fang, Danyi Wen, Yajun Xu

Journal Article

Capacity of human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-likecells: a preclinical study

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation

Journal Article

Orlistat induces ferroptosis-like cell death of lung cancer cells

Journal Article

Metabolism and immunity in breast cancer

Deyu Zhang, Xiaojie Xu, Qinong Ye

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration

Siming Yang, Sha Huang, Changjiang Feng, Xiaobing Fu

Journal Article

Mesenchymal stem cells hold promise for regenerative medicine

Shihua Wang, Xuebin Qu, Robert Chunhua Zhao

Journal Article

Highlights for special issue on “Large Animal Stem Cells”

Jianyong HAN

Journal Article

GID complex regulates the differentiation of neural stem cells by destabilizing TET2

Journal Article

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges

Yingchen Li,Guoheng Hu,Qilai Cheng

Journal Article